(Source: American College of Cardiology Foundation) Building upon extensive epidemiological evidence linking insulin resistance to cardiovascular disease (CVD), the recent IRIS (Insulin Resistance Intervention After Stroke) trial adds substantially to our knowledge about the biological interplay between metabolism and atherosclerosis. This has been, to date, a highly controversial area, as most cardiologists know. For decades, investigators have found that resistance to insulin's metabolic actions (typically measured as hyperinsulinemia) is a strong and independent cardiovascular (CV) risk factor. However, because insulin resistance is also associated with a wide variety of other risk...
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